User:Mr. Ibrahem/Pseudohypoparathyroidism

Pseudohypoparathyroidism is a condition that occurs due to resistance to parathyroid hormone (PTH). This results in low calcium and high phosphate, with symptoms including numbness and muscle spasms. Certain types are also associated with obesity, sleep apnea, and intellectual disability. Complications may include arrhythmias, cataracts, and growth hormone deficiency.

It occurs due to a genetic mutation; either inherited from a person's parents or occurring in early development. It may be inherited in an X-linked dominant or autosomal dominant manner. It is divided into type 1a, 1b, 1c, and 2. It differs from hypoparathyroidism by PTH levels being high. Vitamin D levels are generally normal. Confirmation of the diagnosis is by genetic testing.

Treatment is typically with calcitriol to maintain calcium levels in the normal range. If this is not sufficient calcium supplementation may be used. Intravenous calcium gluconate may be used in people with calcium levels bellow 7.5 mg/dL.

Pseudohypoparathyroidism affects 0.3 to 1.1 per 100,000 people. The condition is usually discovered in early childhood. Long term outcomes are variable. The condition was first described in 1942 by Fuller Albright.