User:Mr. Ibrahem/Pyridoxine/doxylamine

Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine (vitamin B6) and doxylamine. It is used for nausea and vomiting of pregnancy (morning sickness); though the benefit is small. It is taken by mouth.

Commons side effects include tiredness, lightheadedness, sleepiness, and a dry mouth. While concerns of birth defects were raised in 1983, these concerns turned out to be unfounded. Use in pregnancy is considered acceptable. How the combination works is unclear. Doxylamine is a first-generation antihistamine.

The combination came into medical use in 1976. A prior formulation that also contained dicyclomine; however, was in use in the United Kingdom since 1958. Based on taking 4 pills per day, the cost in the United Kingdom is £160 per month. The Scottish Medicines Consortium did not consider it cost effective as of 2019. In the United States this amount costs about 190 USD as of 2021.