User:Mr. Ibrahem/Romidepsin

Romidepsin, sold under the brand name Istodax, is a medication used to treat cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphomas (PTCLs). It is used after other treatments have failed. It is given by gradual injection into a vein.

Common side effects include low white blood cells, low platelets, nausea, tiredness, and infection. Other side effects may include tumor lysis syndrome and QT prolongation. Use during pregnancy may harm the baby. It works by blocking an enzyme known as histone deacetylases, bringing about programmed cell death.

Romidepsin was approved for medical use in the United States in 2009. It was refused approval in Europe in 2012. It is obtained from the bacterium Chromobacterium violaceum. In the United States it costs about 3,350 USD per 10 mg dose. A generic version was approved in 2021 in the USA.