User:Mr. Ibrahem/Rosiglitazone

Rosiglitazone, sold under the brand name Avandia and others, is a medication used to treat type 2 diabetes. Metformin is generally the first line medication; with rosiglitazone worsening outcomes. It is taken by mouth. It is also available in combination with metformin or glimepiride.

Common side effects include headache and upper respiratory tract infection. Other side effects may include heart failure, swelling, bone fractures, and liver problems. While there was previous concerns regarding heart attacks, these concerns have not be substantiated. Safety in pregnancy is unclear. It is in the thiazolidinedione class and works by increasing sensitivity to insulin.

Rosiglitazone was patented in 1987 and approved for medical use in the United States in 1999. While it was approved for use in Europe in 2000, it approval was suspended in 2010 due to safety concerns, and withdrawn in 2015. It was withdrawn from the market in India in 2010, and New Zealand in 2011. In the United States a month of treatment costs about 150 USD as of 2021.