User:Mr. Ibrahem/Sacubitril/valsartan

Sacubitril/valsartan, sold under the brand name Entresto among others, is a combination medication used for heart failure with reduced ejection fraction. It may be used to replace an ACE inhibitor or an angiotensin receptor blocker. It is taken by mouth.

Common side effects include low blood pressure, cough, kidney problems, and high potassium. Other side effects may include angioedema. Use in pregnancy may harm the baby. It contains sacubitril, a neprilysin inhibitor, and valsartan, a angiotensin receptor blocker. The combination is sometimes known as an "angiotensin receptor-neprilysin inhibitor" (ARNi).

Sacubitril/valsartan was approved for medical use in the United States and Europe in 2015. It was approved in Australia in 2016. In the United States it costs about 575 USD per month as of 2021. This amount in the United Kingdom costs the NHS about £92.