User:Mr. Ibrahem/Selumetinib

Selumetinib, sold under the brand name Koselugo, is a medication used to treat plexiform neurofibromas found in neurofibromatosis type I (NF-1). It may be used in those over the age of 1 year. It is taken by mouth twice per day.

Common side effects include headache, abdominal pain, tiredness, muscle pain, rash, fever, and itchiness. Other side effects may include inflammation of the heart, eye problems, muscle breakdown, and bleeding. Use in pregnancy may harm the baby. It works by blocking mitogen-activated protein kinase kinase 1 and 2.

Selumetinib was approved for medical use in the United States in 2020 and Europe in 2021. In the United States a year of treatment at a dose of 25 mg twice per day costs about 150,000 USD as of 2021.