User:Mr. Ibrahem/Serotonin–norepinephrine reuptake inhibitor

Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of medication primarily used for major depressive and generalized anxiety disorder, when SSRIs are not effective. Other uses may include fibromyalgia. There is no clear evidence they are more effective than SSRIs; however, there are concerns of greater side effects.

Common side effects include constipation, sleepiness, dry mouth, and sexual dysfunction. Other side effects may include suicide, particularly in those under the age of 25, low sodium, bleeding, high blood pressure, and serotonin syndrome. Stopping suddenly can result in withdrawal. They are believed to work by blocking the reuptake of serotonin and norepinephrine by neurons.

The first SNRI, venlafaxine, was approved for medical use in the United States in 1993. Some are available as generic medication and are relatively inexpensive. In 2018 duloxetine was the 36th and velafaxine was the 50th most commonly prescribed medication in the United States.