User:Mr. Ibrahem/Siltuximab

Siltuximab, sold under the brand name Sylvant, is a medication used to treat multicentric Castleman’s disease (MCD) in those who have neither HIV nor human herpesvirus-8 (HHV-8). It is given by gradual injection into a vein.

Common side effects include rash, itchiness, weight gain, swelling, low platelets, and upper respiratory infections. Other side effects may include anaphylaxis and gastrointestinal perforation. It is a monoclonal antibody which binds to interleukin 6 (IL-6) thus blocking its activity.

Siltuximab was approved for medical use in the United States and Europe in 2014. In the United Kingdom it costs the NHS about £1,700 per 400 mg vial as of 2021. This amount in the United States costs about 5,200 USD.