User:Mr. Ibrahem/Sirolimus

Sirolimus, also known as rapamycin, is a medication primarily used to prevent organ transplant rejection and treat lymphangioleiomyomatosis. For kidney transplant it is a second line treatment. It is taken by mouth.

Common side effects include infection, fever, poor wound healing, diabetes, protein in the urine, rash, and swelling. Other side effects may include lymphoma, anaphylaxis, angioedema, kidney problems, and progressive multifocal leukoencephalopathy. It is an mTOR inhibitor and works by decreasing the activation of T cells and B cells.

Sirolimus was isolated in 1972 and approved for medical use in the United States in 1999 and Europe in 2001. It is available as a generic medication. A month of treatment in the United States at 2 mg per day costs about 225 USD as of 2021. This amount in the United Kingdom costs the NHS £172 as of 2023. It is sold under the brand name Rapamune.