User:Mr. Ibrahem/Sitagliptin

Sitagliptin, sold under the brand name Januvia among others, is a medication used to treat diabetes type 2. In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea. It is taken by mouth. It is also available within a single pill as metformin/sitagliptin.

Common side effects include headaches, swelling of the legs, and upper respiratory tract infections. Serious side effects may include angioedema, low blood sugar, kidney problems, pancreatitis, and joint pain. Whether use in pregnancy or breastfeeding is safe is unclear. It is in the dipeptidyl peptidase-4 (DPP-4) inhibitor class and works by increasing the production of insulin and decreasing the production of glucagon by the pancreas.

Sitagliptin was developed by Merck & Co. and approved for medical use in the United States in 2006. A month's supply in the United Kingdom costs the NHS about £33.26 per month as of 2020. In the United States the wholesale cost of this amount is about US$405.00. In 2017, it was the 95th most commonly prescribed medication in the United States, with more than eight million prescriptions.