User:Mr. Ibrahem/Statin

Statins, also known as HMG-CoA reductase inhibitors, are a class of medication primarily used for high cholesterol and heart disease. They are used both to prevent heart disease in those at high risk, as well as in those with established heart disease. They are taken by mouth.

Common side effects include headache, constipation, and an upset stomach. Serious side effects may include muscle breakdown, liver problems, and diabetes mellitus. Use is not recommended during pregnancy or breastfeeding. They inhibit the enzyme HMG-CoA reductase which decreases the production of cholesterol and triglycerides.

Statins were discovered in 1971 and lovastatin came into medical use in 1987. A number of statins are available as generic medication and are relatively inexpensive. They are the most common cholesterol-lowering medication. In 2018 atorvastatin was the most prescribed medication in the United States and simvastatin was the 10th most prescribed.