User:Mr. Ibrahem/Tacrolimus

Tacrolimus is a medication used by mouth or by injection to prevent rejection after organ transplant. Levels of the medication should be regularly monitored. As a cream it is used for moderate to severe eczema or psoriasis when other treatments are not sufficient.

Common side effects when take by mouth or injection include kidney problems, diarrhea, nausea, high blood potassium, and infection. Other side effects may include high blood sugar, neurological problems, lymphoma, and anaphylaxis. Common side effects when used as a cream include itchiness, headache, and red skin. It is unclear if the cream is safe in pregnancy. Tacrolimus is a calcineurin inhibitor. It is believed to works by decreasing the activity of T cells.

Tacrolimus was discovered in 1987, and approved for medical use in the United States in 1994. It is available as a generic medication. It is on the World Health Organization's List of Essential Medicines. In the United Kingdom 50 tablets of 5 mg costs the NHS about 206 pounds in 2020. In the United States this amount costs about 82 USD as of 2020 while 30 grams of 0.1% cream costs about 36 USD. It was initially made from a soil sample in Japan that contained the bacterium Streptomyces tsukubaensis.