User:Mr. Ibrahem/Telotristat

Telotristat, sold under the brand name Xermelo, is a medication used to treat diarrhea due to carcinoid syndrome. It is taken by mouth, three times per day. It is used together with a somatostatin like agent.

Common side effects include abdominal pain, liver problems, and tiredness. Other side effects may include constipation. Smaller doses may be required in those with liver problems. Use during pregnancy is not recommended. It works by blocking tryptophan hydroxylase, thereby decreasing the production of serotonin.

Telotristat was approved for medical use in the United States and Europe in 2017. In the United States it costs about 8,000 USD per month as of 2021. This amount in the United Kingdom costs the NHS about £1,100.