User:Mr. Ibrahem/Tetanus vaccine

Tetanus vaccine, also known as tetanus toxoid (TT), is an inactive vaccine used to prevent tetanus. It is used in combination with diphtheria vaccine. During childhood, five doses are recommended, with a sixth given during adolescence. After three doses, almost everyone is initially immune. Some countries just give six doses; while others, such as the USA, recommend boosters every ten years. A booster shot may be given within 48 hours of an injury to people whose immunization is out of date. For people with high-risk injuries who are not fully immunized, tetanus antitoxin may also be recommended. Confirming that pregnant women are up to date on tetanus immunization during each pregnancy can prevent both maternal and neonatal tetanus.

The vaccine is very safe, including during pregnancy and in those with HIV/AIDS. Redness and pain at the site of injection occur in between 25% and 85% of people. Fever, feeling tired, and minor muscle pain occurs in less than 10% of people. Severe allergic reactions occur in less than one in 100,000 people.

A number of vaccine combinations include the tetanus vaccine, such as DTaP and Tdap, which contain diphtheria, tetanus, and pertussis vaccines, and DT and Td, which contain diphtheria and tetanus vaccines. DTaP and DT are given to children less than seven years old, while Tdap and Td are given to those seven years old and older. The lowercase d and p denote lower strengths of diphtheria and pertussis vaccines.

Tetanus antiserum was developed in 1890, with its protective effects lasting a few weeks. The tetanus toxoid vaccine was developed in 1924, and came into common use for soldiers in World War II. Its use resulted in a 95% decrease in the rate of tetanus. It is on the World Health Organization's List of Essential Medicines. The wholesale cost in the developing world is between 0.17 and 0.65 USD per dose. In the United States, a course of tetanus vaccine is between 25 and 50 USD.