User:Mr. Ibrahem/Tezacaftor/ivacaftor

Tezacaftor/ivacaftor, sold under the brand name Symdeko, is a combination medication of tezacaftor and ivacaftor used to treat cystic fibrosis. It is only used in people with specific mutations. It is taken by mouth.

Common side effects include nausea, headache, diarrhea, and dizziness. Other side effects may include liver problems and cataracts. In those with significant liver problems a lower dose may be required. Tezacaftor increases the number of CFTR while ivacaftor increases the ability of CFTR.

The combination was approved for medical use in the United States and Europe in 2018. In the United States it costs about 304,000 USD per year as of 2021. It became available in the United Kingdom in 2020 at a cost of about £82,000 per year.