User:Mr. Ibrahem/Tioguanine

Tioguanine, also known as thioguanine or 6-thioguanine (6-TG) is a medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and chronic myeloid leukemia (CML). Long-term use is not recommended. It is given by mouth.

Common side effects include bone marrow suppression, liver problems and inflammation of the mouth. It is recommended that liver enzymes be checked weekly when on the medication. People with a genetic deficiency in thiopurine S-methyltransferase are at higher risk of side effects. Avoiding pregnancy when on the medication is recommended for both males and females. Tioguanine is in the antimetabolite family of medications. It is a purine analogue of guanine and works by disrupting DNA and RNA.

Tioguanine was developed between 1949 and 1951. It is on the World Health Organization's List of Essential Medicines. The wholesale price in the developing world is about 7.07 USD per 40 mg pill as of 2014. In the United Kingdom this amount costs the NHS about 4.14 pounds.