User:Mr. Ibrahem/Tolvaptan

Tolvaptan, sold under the brand name Samsca among others, is a medication used to treat low sodium due to heart failure or syndrome of inappropriate antidiuretic hormone (SIADH). It is also used for autosomal dominant polycystic kidney disease (ADPKD). It is taken by mouth. Effects begin within 4 hours.

Common side effects include thirst, nausea, and rapid increase in sodium. Other complications may include osmotic demyelination syndrome, liver failure, and high potassium. It is a vasopressin-2 receptor (V2) antagonist which works by increasing urine production.

Tolvaptan was approved for medical use in the United States and Europe in 2009. A generic version was approved in 2020, though was not available commercially as of 2021. In the United States 10 tablets of 30 mg costs about 3,800 USD as of 2021. This amount in the United Kingdom costs the NHS about £750.