User:Mr. Ibrahem/Trabectedin

Trabectedin, sold under the brand name Yondelis, is a medication used to treat advanced soft-tissue sarcoma and ovarian cancer. It is used when other treatments are no longer effective. It is given by gradual injection into a vein. Dexamethasone is used to decrease the risk of side effects.

Common side effects include low neutrophils, nausea, liver problems, low red blood cells, tiredness, low platelets, and diarrhea. Other side effects may include muscle breakdown, heart failure, and decreased fertility. Use during pregnancy may harm the baby. Death occurs due to the medication in 1 to 2% of people. It is an alkylating agent.

Trabectedin was approved for medical use in Europe in 2007 and the United States in 2015. It was initially designated an orphan medicine in Europe in 2001. In the United Kingdom 1 mg costs the NHS about £1,400 as of 2021. In the United States this amount costs about 3,250 USD. It was originally derived from a sea squirt.