User:Mr. Ibrahem/Trifluridine/tipiracil

Trifluridine/tipiracil, sold under the brand name Lonsurf, is a combination medication used to treat metastatic colorectal cancer or gastric cancer, in those in who other treatments have failed. It is taken by mouth.

The most common side effects are low neutrophils, tiredness, nausea, fever, hair loss, and low red blood cells. Other serious side effects include diarrhea. Use during pregnancy may harm the baby. It is a combination of trifluridine, a nucleoside analog, and tipiracil, a thymidine phosphorylase blocker. Tipiracil prevents breakdown of trifluridine, thus increasing its level.

Trifluridine/tipiracil was approved for medical use in the United States in 2015 and Europe in 2016. In the United Kingdom 20 tablets of 20 mg trifluridine cost the NHS £2,000 as of 2021. This amount in the United States costs about US$5,000.