User:Mr. Ibrahem/Trimethoprim/sulfamethoxazole

Trimethoprim/sulfamethoxazole (TMP/SMX), also known as co-trimoxazole among other names, is an antibiotic used to treat a variety of bacterial infections. It is used for urinary tract infections, methicillin-resistant Staphylococcus aureus (MRSA) skin infections, travelers' diarrhea, respiratory tract infections, and cholera, among others. It may be used both to treat and prevent pneumocystis pneumonia and toxoplasmosis in people with HIV/AIDS. It can be given by mouth or intravenously.

Common side effects include nausea, vomiting, rash, and diarrhea. Severe allergic reactions and Clostridium difficile diarrhea may occasionally occur. Its use in pregnancy is not recommended. It appears to be safe for use during breastfeeding as long as the baby is healthy. TMP/SMX generally results in bacterial death. It works by blocking the making and use of folate by the microorganisms. It consists of one part trimethoprim to five parts sulfamethoxazole.

TMP/SMX was first sold in 1974. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication and is relatively inexpensive. In 2017, it was the 121st most commonly prescribed medication in the United States, with more than six million prescriptions.