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The Connectivity Map
The Connectivity Map, or CMap, is a catalog of transcriptional responses of human cells to perturbation from chemical and genetic treatments. Its database contains 1.3M gene expression signatures that can be used to find relationships between diseases, genes, and therapeutics. Changes in gene expression that arise from a disease or a perturbation can be compared for similarity with those arising from another disease or different perturbations. Cases that exhibit a high similarity are termed "connected." The biomedical community has used these connections to develop hypotheses for a variety of disease treatments, including cancers, neurological diseases, and infectious diseases.