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Overview
Archaeogenetics is the study of ancient DNA 70 years and older using various molecular genetic methods and DNA resources. This form of genetic analysis can be applied to human, animal, and plant specimens. Ancient DNA can be extracted from various fossilized specimens including bones, eggshells, and artificially preserved tissues in human and animal specimens. In plants, Ancient DNA can be extracted from seeds, tissue, and in some cases, feces. Archaeogenetics provides us with genetic evidence of ancient population group migrations, domestication events, and plant and animal evolution. When analyzing aDNA researchers will often use mtDNA as a source for analysis due to the absence of recombination. The ancient mtDNA cross referenced with the DNA of relative modern genetic populations allows researchers to run comparison studies.

Archaeogenetics receives its name from the Greek word arkhaios meaning ancient, and the term genetics, meaning the study of heredity. The term archaeogenetics was conceived by archaeologist Colin Renfrew.

Early Work
Ludwik Hirszfeld (1884–1954)

Ludwik Hirszfeld was a Polish microbiologist and serologist who was the President of the Blood Group Section of the Second International Congress of Blood Transfusion. He founded blood group inheritance with Erich von Dungern in 1910, and contributed to it greatly throughout his life. He studied ABO blood groups. In one of his studies in 1919, Hirszfeld documented the ABO blood groups and hair color of people at the Macedonian front, leading to his discovery that the hair color and blood type had no correlation. In addition to that he observed that there was a decrease of blood group A from western Europe to India and the opposite for blood group B. He hypothesized that the east-to-west blood group ratio stemmed from two blood groups consisting of mainly A or B mutating from blood group O, and mixing through migration or intermingling. A majority of his work was researching the links of blood types to sex, disease, climate, age, social class, and race. His work led him to discover that peptic ulcer was more dominant in blood group O, and that AB blood type mothers had a high male-to-female birth ratio.

Arthur Mourant (1904–1994)

Arthur Mourant was a British hematologist and chemist. He received many awards, most notably Fellowship of the Royal Society. His work included organizing the existing data on blood group gene frequencies, and largely contributing to the genetic map of the world through his investigation of blood groups in many populations. Mourant discovered the new blood group antigens of the Lewis, Henshaw, Kell, and Rhesus systems, and analyzed the association of blood groups and various other diseases. He also focused on the biological significance of polymorphisms. His work provided the foundation for archaeogenetics because it facilitated the separation of genetic evidence for biological relationships between people. This genetic evidence was previously used for that purpose. It also provided material that could be used to appraise the theories of population genetics.

William Boyd (1903–1983) William Boyd was an American immunochemist and biochemist who became famous for his research on the genetics of race in the 1950s. During the 1940s, Boyd and Karl O. Renkonen independently discovered that lectins react differently to various blood types, after finding that the crude extracts of the lima bean and tufted vetch agglutinated the red blood cells from blood type A but not blood types B or O. This ultimately led to the disclosure of thousands of plants that contained these proteins. In order to examine racial differences and the distribution and migration patterns of various racial groups, Boyd systematically collected and classified blood samples from around the world, leading to his discovery that blood groups are not influenced by the environment, and are inherited. In his book Genetics and the Races of Man (1950), Boyd categorized the world population into 13 distinct races, based on their different blood type profiles and his idea that human races are populations with differing alleles. Research on blood groups is still one of the most abundant information sources regarding inheritable traits linked to race, even though racial distinction is now viewed as more complex.