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However, many animal and clinical studies involving curcumin have shown positive results. Nelson et al. maintains that despite the controversy surrounding the usage of curcumin, there is much to be explored. Thus, reports that have detailed its relatively obscure pharmacological role do not represent the complete picture.

Possible Roles in Disease Pathogenesis
Antioxidant Role

Currently, the antioxidant properties of curcumin have been extensively studied and confirmed. Ak et al. demonstrated that curcumin mediated oxidative stress via mechanisms such as neutralization of free radicals like O2- and DPPH. Due to the resonance of the symmetrical dual phenol groups in curcumin, it is able to act as a proton donator (brønsted-lowry acid) and therefore effectively disable radical species.

Researchers have therefore attributed curcumin to the possible mitigation of many conditions, particularly to the following diseases:
 * Diabetic Cardiomyopathy
 * Osteoarthritis
 * Cancer
 * Depression
 * Oral Disease
 * Inflammatory Bowel Diseases

Methods to Improve Bioavailability
Adjuvants such as piperene, phytosomes, and liposomes all have improved the bioavailability of curcumin.