User:Mtv52/RecklinghausenDraft

Link to original article: Friedrich Daniel von Recklinghausen

Early Life
Recklinghausen was born in Gütersloh, Germany, in 1833. He was the son of Friedrich Christoph von Recklinghausen and Friederike Charlotte Zumwinkel (maiden name). His father was an elementary school teacher and a sexton. His mother died shortly after his birth in 1833. The Recklinghausens were a patrician family putting multiple councilors and mayors in their positions. He went to the elementary school where his father taught in Gütersloh. He then attended high school at Ratsgymnasium, Bielefeld.

Academic background
Recklinghausen studied medicine at the Universities of Bonn, Würzburg and Berlin, earning his doctorate at the latter institution in 1855. Afterwards he studied pathological anatomy under Rudolf Virchow, the father of modern pathology, and obtained his doctorate with Virchow as his advisor. He subsequently undertook an educational journey to Vienna, Rome, and Paris. From 1858 to 1864, Recklinghausen was an assistant at the Pathological Institute in Berlin. In 1864 he became the Professor of Pathological Anatomy at Königsberg before moving to Würzburg 6 months later. He remained a professor at Würzburg until 1872, when he was appointed Professor of General Pathology and Pathological Anatomy at Strassburg until 1906. Henceforth, he remained as a professor emeritus, continuing to teach and conduct research until his death in 1910. At Strassburg he helped to recruit a number of important people to the school, such as anatomist Wilhelm von Waldeyer-Hartz (1836-1921).

Contributions
In 1855 Recklinghausen wrote his inaugural thesis De pyaemiae theoriis, concerning differing theories on Pyaemia.

In 1882 he released a monograph that reviewed previous literature and characterized the tumors of neurofibromatosis type I or NF-1 as neurofibromas, consisting of an intense commingling of nerve cells and fibrous tissue. NF-1 is sometimes referred to as "von Recklinghausen syndrome".

In 1889 he coined the term "haemochromatosis", and was the first to provide the link between haemochromatosis and iron accumulation in body tissue. Recklinghausen published his findings in a treatise titled Hämochromatose (1889).

He is credited with establishing a method for staining lines of cell junctions with silver, a procedure that led to Julius Friedrich Cohnheim’s research on leukocyte migration and inflammation. In a monograph published posthumously in 1910, he coined the term oncosis (derived from ónkos, meaning swelling) in a monograph published posthumously. This term is sometimes used to describe Ischemic cell death. In addition, he is credited with performing important studies on the heart and circulation.

Written works

 * Die Lymphgefässe und ihre Beziehung zum Bindegewebe (1862). Here he looked into using silver to show the junction of cells and how the connective tissues communicate through lymphatics.
 * Ueber Eiter- und Bindegewebskörperchen in Virchow's Archiv für pathologische Anatomie und Physiologie, und für klinische Medicin, Berlin, (1863), 28: 157-197. Here Recklinghausen described granular cells in the frog mesentery, later named "mast cells" by Paul Ehrlich (1854-1915).
 * Über die multiplen Fibrome der Haut und ihre Beziehung zu den multiplen Neuromen. Festschrift für Rudolf Virchow. Berlin, (1882). (treatise on Recklinghausen’s disease). About the multiple fibroids of the skin and their relationship to the multiple neuromas.
 * Handbuch der allgemeinen Pathologie des Kresilaufes und der Ernährung. In Theodor Billroth and Georg Albert Lücke, publishers: Deutsche Chirurgie, Lfg. 2, 3, Stuttgart, (1883). Translates to handbook of general pathology of cancer and nutrition.
 * Hämochromatose. Tageblatt der Naturforschenden Versammlung (1889), Heidelberg, 1890: 324.
 * Ueber Akromegalie. Virchow's Archiv für pathologische Anatomie und Physiologie und für klinische Medizin, Berlin, (1890), 119: 36.
 * Demonstration von Knochen mit Tumor bildender Ostitis deformans. Tageblatt der Naturforschenden Versamlung 1889. Heidelberg, (1890), p 321.
 * Osteoplastische Carcinose in ihren gegenseitigen Beziehungen. Festschrift für Rudolf Virchow. Berlin, Georg Reimer Verlag, 1891