User:MudPhudTLC/sandbox

Receptor
Thiazide receptor is a thiazide-sensitive NaCl cotranspoter.

The exact way that thiazides reduce blood pressure throughout the body is not fully understood.

It is known that thiazide diuretics bind to the luminal side of the thiazide receptor to inhibit NaCl cotransport.

'' Inhibiting the thazide receptor increases the amount of NaCl that remains in the lumen and decreases NaCl in the renal interstitium. [TRUE? REF?] ''

Too much inhibition of the renal NaCl cotransporter can cause hypokalemia (low blood potassium).

Electrolyte Balance
Calcium absorption in the distal tubule is increased due the high lumenal NaCl and low interstitial NaCl.