User:Mukhopadhyayd

Sumoylation of proteins is a highly dynamic process and is readily reversed by a class of cysteine proteases (C48, EC 3.4.22.68), collectively known as deSUMOylating enzymes. Like most of the SUMO pathway enzymes deSUMOylating enzymes were first identified in baker's yeast (Saccharomyces cerevisiae). While yeast has only two deSUMOylating enzymes, Ubl specific protease (Ulp) 1 and 2 ) there are multiple sumo proteases in higher eukaryotes. In mammals there are atleast six Sentrin/SUMO specific proteases (Senp1-3 and 5-7), whereas in Arabidopsis there are seven . Senp1 and 2 are localized at the nuclear pore, Senp3 and 5 are localized in the nucleolus and Senp6 and 7 are localized in the nucleoplasm. The Senp pairs are closely related to each other both evolutionarily as well as biochemically