User:Muruj Qadi/sandbox

Wikipedia Draft
As an example of functional mechanism of Anti-Sigma factors that it’s usually can play an important role instead of being a sigma factors destroyers since they inhibit some cell processes and activate another depending on some researches has been done. Researchers has study several anti-sigma factor activities in the cell such as RsrA (Redox-sensitive), which is a key sensor of thiol–disulphide and a negative regulator of σR (binds σR and inhibits σR‐directed transcription only in vitro), what means that it needs some sensitive conditions to happen. They are conclude by using Thioredoxin that it’s able to reduce the oxidize RsrA.

Another Anti-sigma factor example is sigma factor σH which regulate the somatic stress response and the morphological differentiation in Streptomyces coelicolor as the studies results. From the same study we can conclude that every anti-sigma factor has a specific gene location to act and affect in the cell.

As a negative feedback interaction, anti-sigma factor in E-coli, help the cell or allow it to control the gene expression in a particular environment terms. As soon as these terms disappeared, the gene expression complete the circle.

T4 bacteriophage uses anti- sigma factor to ruin the Escherichia coli polymerase in order that direct exclusive transcription of its own genes.

(AsiA is an anti-sigma factor gene that it’s  required for bacteriophage T4 to be developed.)What means that AsiA is an essential anti sigma factor in bacteriophage.

Refrences
http://emboj.embopress.org/content/18/15/4292?casa_token=TEZjwYYZXUUAAAAA%3Aqa0ues8XSc1IUQ5b8uWLPD19PUeSeCutgEtxVkPhj3WKKYkbFY8-PIyAOaxq2J47YzAqEe8IEo5-YoojkmxCjA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861889/

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2958.1992.tb01771.x

https://www.sciencedirect.com/science/article/pii/S1369527499800241

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