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Hopkins v. Clemson Agricultural College of South Carolina, 221 U.S. 636 (1911), was a decision by the Supreme Court of the United States holding that sovereign immunity did not bar a cause of action for inverse condemnation from being brought in a federal court. The case involved Clemson University shortly after its founding.

Procedural history and factual background
Dr. John Hopkins owned land along the Seneca River in South Carolina which he used as a farm from 1880 until 1895. In 1895, Clemson University, then called Clemson Agricultural College, erected a high embankment on the eastern side of the Seneca River to protect its lands from overflow. As a result of this embankment, when the Seneca River had a higher level of water than normal, Dr. Hopkins' land was flooded. Dr. Hopkins alleged that his land was "practically ruined" as a result of this flooding.