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A handful of clinical trials have been conducted to investigate the effectiveness of Pygeum in treating Benign Prostatic Hyperplasia. The trial studies were done comparing P. Africanum to a placebo, not a pharmaceutical drug. These researchers found that there was an improvement in patients’ symptoms after taking an extract of P. Africanum compared to placebo. Several of the studies that were analyzed used a standardized extract of the P. Africanum at a dose of 100mg to 200mg per day. The outcomes evaluated included urine flow, the number of times an individual had to urinate at night as well as urinary retention. These were all reduced in the patients that took part in the clinical trials. Therefore, a standardized extract of P. Africanum does seem to have clinical importance in reducing the symptoms of BPH. Stomach upset including nausea and abdominal pain were reported as side effects, but overall this herb was well tolerated.

However, it is important to note that not all researchers agree that P. Africanum has clinical significance. Some believe that the doses used in the clinical trials were too high and therefore might not be practical to use in a clinical setting. Additionally, some of the studies that show advantages of P. Africanum in BPH did not meet certain guideline criteria. An explanation of the exact ingredients of the extract that make it effective as well as the actual pathway of how Pygeum reliefs BPH symptoms are some of the guidelines that were not described in some clinical trials. There are no known interactions between P. Africanum with other medicines, food, herbal supplements or disease.