User:NZVortex/Self-controlled case series

The self-controlled case series (also known as SCCS) is an epidemiological study design which measures the association between an exposure and an event within individuals. The SCCS method only uses data from cases, those who have the event of interest. As the association is within individuals with the event of interest, it is self-controlled and case series.

The method was originally developed for vaccine safety, however has also had applications in drug safety.

Assumptions

 * 1) Event independent exposure, the method assumes that exposure is independent from the event.

Advantages

 * 1) Controls for time invariate confounders, as SCCS is self-controlled, it controls for any confounders within individuals that are time invariate.