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Introduction
HSH2D (hematopoietic SH2 domain containing) is a gene that encodes the hematopoietic SH2 domain-containing protein in Homo sapiens. It is located at 19p13.11 on chromosome 19. The function of HSH2D is still poorly understood, it has been studied alongside other human genes with antiviral properties, but no definitive role was discovered. The mRNA has 7 exons and is 2403 bp in length. The mature protein contains an SRC homology 2 domain, four phosphotyrosine binding pockets, two hydrophobic binding pockets, and is 352 amino acids in length.

Gene
HSH2D is located at 19p13.11 on the plus strand. Common aliases of the gene include HSH2 and ALX. The mRNA encodes two main isoforms. Isoform 1, the longest isoform, contains 7 exons and the entire gene spans from 16134028 to 16158575.

Protein
There are two isoforms of HSH2D. Isoform 1, the longest isoform, consists of 7 exons and is 295 amino acids in length. The main feature of the HSH2D protein is the SH2 domain, which is a common feature in proteins involved in receptor tyrosine kinase adaptor proteins. The protein contains phosphotyrosine binding pockets and hydrophobic binding pockets. Isoform 2 consists of 6 exons and is 295 amino acids in length.

Homology
HSH2D has protein orthologs in several species, with higher sequence similarity in primates and other mammals. Orders of organisms include primates, rodents, carnivores, birds, reptiles, amphibians, one fish (Australian ghostshark), two invertebrates, and one protist. The most distant common ancestor diverged from humans 928 million years ago.

Clinical Significance
The HSH2D protein has been studied along other genes predicted to be involved in the immune system. One study found it to be involved in "apoptosis, wound healing, vascular endothelial growth factors, membrane-associated intracellular trafficking, biogenesis of lipid droplets and collagen remodeling ". Another study determined HSH2D to be highly expressed in ulcerative colitis.