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Edible clay
Different types of edible clay include Bentonite, Terramin and Montmorillonite clay.

Montmorillonite-containing bentonite clays have also been used for thousands of years as a remedy for infections, indigestion, and other medical problems by both appying wet clay topically to the skin as a poultice and by ingesting it. A recent article in The Journal of Antimicrobial Chemotherapy also found that certain iron-rich clay was effective in killing bacteria.

A more recent, and more limited, use is as a specially formulated spray applied to especially organic fruits, vegetables, and other vegetation to repel or deter insect damage, and at least in the case of apples, to prevent sun scald. A traditional use is to soothe an upset stomach, similar to the way parrots (and later, humans) in South America originally used it.

Peruvian parrots behave like sophisticated human tourists and hunter-gatherers. Their preferred soils were found to have a much higher cation-exchange capacity than adjacent bands of rejected soils -- because they are rich in the minerals smectite, kaolin and mica. In their capacity to bind quinine and tannic acid, the preferred soils surpass the pure mineral kaolinate and surpass or approach pure bentonite. Clearly, parrots would be well qualified for jobs as mining prospectors.

Gilardi et al. confirmed this hypothesis with two sets of bioassays. First, they exposed brine shrimp (the toxicologist's test animal of choice) to extracts of seeds routinely consumed by macaws. Many of the brine shrimp died, confirming the toxicity of the parrots' diet. But mixing the solutions or extracts with soil preferred by parrots reduced the effective toxin loads by 60-70% and improved shrimp survival. Second, Amazon parrots were given an oral dose of the alkaloid quinidine with or without preferred soil, and quinidine levels were measured in the parrots' blood for three hours as absorption took place from the gut. Providing soil along with the quinidine reduced absorbed quinidine blood levels by 60%.

What is the evolutionary significance of plant toxins and animal anti-toxin behaviour? From a plant's evolutionary perspective, a seed should be high in nutrients to support germination and seedling growth; the ripe fruit around the seed should also be nutrient-rich and attractive to animals, encouraging them to pluck and eat the fruit and disperse the seed. On the other hand, the seed itself should be repulsive to animal consumers, inducing them to regurgitate or defaecate it, and the unripe fruit should be repulsive, lest animals harvest it before the seed is viable. From an animal's evolutionary perspective, an ability to defeat the plant's toxin defences would enable it to obtain the nutrients in the seed as well as those in the ripe fruit, and to outcompete other animal consumers by harvesting the fruit while it is unripe and still unpalatable to them.

Any textbook of animal biology describes the resulting evolutionary arms race, in which plants evolve increasingly potent toxins (such as strychnine and quinine), and animals evolve increasingly potent means of detoxification. While enzymatic detoxification has previously received the most attention, the work of Gilardi et al.10 and the wide distribution of geophagy among animal herbivores suggest an additional important means of detoxification by adsorption on ingested soil minerals.