User:Naki0515/Amino acid activation

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It's the hydrolyzation of the ATP that makes peptide bond formation a favorable reaction because of the inorganic phosphate acting as a leaving group, resulting in a high negative free energy.

However, depending on the chirality of the amino acid, an aminoacyl-tRNA-synthase can actually disrupt the ester bond between D-amino acids and tRNA. This can happen if there is an editing domain that's lacking in the active site of that aminoacyl-tRNA-synthase.

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