User:NarLim

Kangri cancer is a type of squamous-cell carcinoma of the skin. It is found only in Kashmir in the northwest of the Indian subcontinent. It occurs on the lower abdomen and inner thighs and is due to the use of a kangri - a baked clay pot weaved around with wicker-work, used as a source for warmth by people in Kashmir during cold weather. The condition was described in 1819 at the Kashmir Mission Hospital and its cause was recognized in the early 20th century as described by Arthur Neve.

Despite current knowledge of the cause of this condition, cases are still being reported.

Other conditions associated with prolonged use of the kangri in this fashion include erythema ab igne, a reticulate hypermelanosis with erythema.

Signs and Symptoms
Most cases (80%) of squamous cell carcinoma attributed to ultraviolet radiation present in areas of the skin that are usually more exposed to sunlight (e.g., head, face, neck). As a particular form of squamous cell carcinoma, Kangri cancer is more often associated with the abdomen, thigh, and leg regions due to the usage and positioning of kangri pots, which come in close contact with these anatomical features.

Over time, the use of Kangri pots to keep warm results in erythema ab igne, keratotic growth that “take the shape of superficial, serpegenous, reticular blackish brown colored lesions.” Eventually, the cells at the lesion site become more irregular in shape and form; the lesions “ulcerate” and may become itchy and bloody. The resulting growth is the presentation of Kangri cancer.

Risk Factors
Use of the kangri pot has been correlated with the risk of Kangri cancer. The pot holds hot wood and charcoal, and as a unit, the pot is put in direct contact with the skin of the abdomen and the thigh areas as a way to keep warm during winters in north India. Elements that are believed to contribute to the development of Kangri cancer are heat, burning wood particles, smoke, soot, and tar of burnt chinar leaves that could also be used as a fuel source for burning in the production of heat.

In one study, researchers noted kangri pot usage patterns and found that Kangri cancer “patients gave the history of using the Kangri especially for 3-4 winter months [...] every year for 5-6 hours daily.”

Genetic Mutations and Susceptibility
Beyond the behavioral risk factor of prolonged usage of Kangri pots, researchers have begun to look at genetic mutations that may make some people more predisposed to develop Kangri cancer.
 * In one study, compared to a control group, people with Kangri cancer were found to be approximately twice as likely to have a mutation in the TP53 gene (codon 72 polymorphism). Patients with higher grade tumors exhibited more proline amino acid mutations at this site.
 * Another study confirmed this association of Kangri Cancer and TP53 mutations, specifically substitutions and insertions, in 40% of the Kangri cancer patients who were studied. The researchers observed a significant correlation with mutation status and age as well as with the presence of lymph nodes in patients. TP53 may, in the future, serve as “potential molecular marker and prognostic tool” for Kangri cancer. Furthermore, PTEN mutations were found in two of thirty patients studied; though due to the small sample size, no useful conclusions could be postulated.
 * Two polymorphisms of the HSP70 gene were discovered to be correlated with “poor prognosis” of Kangri cancer; the “Hsp70-2 A/G or G/G and Hsp70homC/C genotypes” could potentially be utilized to measure risk of Kangri cancer development as well as to predict prognosis.

Prognosis
A research article from 1923 notes that the “average duration of life” in those with Kangri cancer is about fifteen months, though there have been records of people dying within one year and living for more than twenty years with Kangri cancer. Updated life expectancy is not found in more recent scientific publications.

However, in 2013, it was noted that the progression from erythema ab igne to squamous cell carcinoma, manifesting as Kangri cancer, was between one to two decades.

It has been reported that about one-third to one-half of patients with Kangri cancer show metastasis to local lymph nodes.

Surgery
In the treatment of Kangri cancer, surgery is, most often, the first-line course of action.

External Beam Radiotherapy
External beam radiotherapy has been used in one person to prevent the relapse and growth of tumor metastases to the head and neck regions. The prophylactic treatments have been noted as “encouraging” in this one case, reducing some tumors and eliminating others.

Another study with a couple of the same authors found that radiotherapy after surgery helped with the reduction and cure of head and neck tumors in additional cases. The researchers suggest that external beam radiotherapy should be part of the treatment course for patients who have or at risk of developing tumors in the head and neck areas.

Epidemiology
The first case of Kangri cancer was reportedly recognized in 1819.

The incidence of Kangri cancer is higher for the elderly, those who are at least 50 years old.

There is no definitive predominance of Kangri cancer in either males or females. Some studies may point to higher prevalence in males while others observed higher prevalence in females.

In scientific literature, Kangri cancer has only been attributed to the Kashmir region of northern India due to the traditional use of kangri pots. Kangri cancer is limited to this population, and thus, relatively little is known still, and there is much to be studied about the condition.