User:Nb12k/sandbox

Medicine and DNA repair modulation[edit source]
Main article: DNA repair-deficiency disorder

Hereditary DNA repair disorders[edit source]
[I will include another disease (Rothmund -Thomson syndrome)resulting from DNA repair deficiencies and link it to an existing Wiki page]//discovered Rothmund Thomson syndrome by reading article on RecQL4 helicase DNA repair deficiency

[I plan on linking an article that ties together DNA repair deficiencies with increased vulnerability of developmental neurons and adding in another sentence(citation #2)]

[I re-worded the content on "segmental progerias" and included an article on the studies of Progeroid syndromes in developmental and cancer biology as well as on aging studies]

Defects in the NER mechanism are responsible for several genetic disorders, including: Mental retardation often accompanies the latter two disorders, suggesting increased vulnerability of developmental neurons.
 * Xeroderma pigmentosum: hypersensitivity to sunlight/UV, resulting in increased skin cancer incidence and premature aging
 * Cockayne syndrome: hypersensitivity to UV and chemical agents
 * Trichothiodystrophy: sensitive skin, brittle hair and nails

The development of the nervous system requires scrutiny in DNA repair mechanisms that can result in neurodegenerative and cancerous syndromes when there is deficiency in these repair processes.

Other DNA repair disorders include: All of the above diseases are often called "segmental progerias" ("accelerated aging diseases") because those that carry the disease undergo impetuous aging and suffer from aging-related diseases at an abnormally young age, while not manifesting all the symptoms of old age. Progeroid syndromes are broadly studied in the growing fields of developmental biology, cancer and aging.
 * Werner's syndrome: premature aging and retarded growth
 * Bloom's syndrome: sunlight hypersensitivity, high incidence of malignancies (especially leukemias).
 * Ataxia telangiectasia: sensitivity to ionizing radiation and some chemical agents
 * Rothmund-Thomson syndrome: skin conditions associated with changes in pigment (Poikiloderma), congenital bone defects and premature aging