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Chemoproteomics is an approach to discovering mechanisms for regulating biological pathways for the purpose of designing new pharmaceutical therapies. It is a chemical proteomic method for pharmacological discovery research.

Introduction
Chemoproteomics can enable drug discovery. It is a method for identifying protein targets and potential off-target activity. Chemoproteomics applies mass spectrometry to analyze proteomes and their functions.

Method
A linker molecule connects a small molecule chemical probe (or library of chemical probes) with an analytically detectable bead or other agent for detection or separation. This method is being used to asses the molecular mechanisms of enzymes, drugs and other small molecules in order to create Activity-Based protein profiles.