User:Neuron2000/Agouti-related peptide

New Section: Role in Hunger Circuitry

- Mark L. Andermann and Bradford B. Lowell, two prominent scientist in the field say:

"...AgRP neurons and the wiring diagram within which they operate can be viewed as the physical embodiment of the intervening variable, hunger." (1)

- This is because stimulation of these neurons can induce robust feeding behavior, in many contexts:

- actual food consumption (2)

- willingness to work for food (3)

- investigating food odors (4)

- But they are rapidly inhibited upon presentation of food and actual feeding (5)

- These neurons signal with the inhibitor neurotransmitter Neuropeptide Y to sustain feeding (6)

- Are sensitive to hunger signals:

- ghrelin is an appetite stimulant, and it increases AGRP activity (7)

- leptin is a satiety signal, it decreases AGRP activity (8)

Sources (Not formatted yet):

https://www.cell.com/action/showPdf?pii=S0896-6273%2817%2930512-3 (1) - Review

https://www.nature.com/articles/nn.2739 (2)

https://www.jci.org/articles/view/46229 (3)

https://www.nature.com/articles/s41586-021-03299-4 (4)

https://www.sciencedirect.com/science/article/pii/S0092867415000768?via%3Dihub (5)

https://elifesciences.org/articles/46348 (6)

https://pubmed.ncbi.nlm.nih.gov/24567905/ (7)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298648/ (8)