User:Neuroscience34/sandbox

"Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing destroyed blood-forming stem cells. Stem cells can be destroyed through cancer treatments such as chemotherapy or radiation, as well as and blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma . PBSCT is now a much more common procedure than its bone marrow harvest equivalent due to the ease and less invasive nature of the procedure. Studies suggest that PBSCT has a better outcome in terms of the number of hematopoietic stem cell (CD34+ cells) yield."

(changed some of the wording to make it more accessible to readers, added source (mayo clinic) to explain reason for donation.)

"Granulocyte colony stimulating factor (GCSF) are naturally occurring glycoproteins that stimulate white blood cell proliferation. Filgrastim is a synthetic form of GCSF produced in E.coli. PBSC donors are given a course of GCSF prior to PBSC collection. The increase in white blood cell proliferation as a result of the Filgrastim ensures better results from the donation. The course is usually given over a 4-day period prior to PBSC collection. The most common side effect of Filgrastim is bone, joint, back, arm, leg, mouth, throat, or muscle pain . Additionally, headache, nausea, vomiting, dizziness, fatigue, rash, loss of appetite, and difficulty falling or staying asleep are common ."

(Changed wording to make it flow better. Added new source (filgrastim injection) and included list of side effects of filgrastim).