User:Nicholas Quinn/Andrew Schally

He developed a new realm of knowledge concerning the brain's control over the body chemistry. Schally explained in his 1977 Nobel Lecture that him, alongside his researchers, dissected 250,000 pig hypothalami in order to isolate 5 mg of the hormone TRH to determine the molecular structure of the hormone. His works also addressed birth control methods and growth hormones. Together with Roger Guillemin he described the neurohormone GnRH that controls FSH and LH.

In 1981 it was demonstrated that GnRH agonistic analogs that Schally had developed between the years of 1972-1978 inhibited the growth of prostate cancer in rats. Alongside Dr. George Tolis, Schally organized the first clinical trial with agonistic analogs of GnRH for patients with advanced prostate cancer in 1982. This method is now the preferred method for treatment for advanced prostate carcinoma, about 70% of patients with prostate cancer utilize a GnRH agonist for their primary method of treatment. The previous method of treatment was based off the research of Charles Huggins, where the most common treatment for advanced prostate cancer was an orchiectomy or the administration of estrogens.

In 2004 after the death of his wife due to thyroid cancer, Schally reports finding comfort in continuing his research on cancer treatment. According to Schally, his discovered methods of treatment for cancer yield less side affects on the patient due to them being analogs of hypothalamic hormones, in contrast to radiation and chemotherapy.

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