User:Nicklao2/sandbox

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This is place to practice clicking the "edit" button and practice adding references (via the citation button). Please see Help:My_sandbox or contact User_talk:JenOttawa with any questions.

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 * Note: Please use your sandbox to submit assignment # 3 by pasting it below. When uploading your improvements to the article talk page please share your exact proposed edit (not the full assignment 3).


 * Talk Page Template: CARL Medical Editing Initiative/Fall 2019/Talk Page Template

Assignment #2
The prevalence of nodular lymphocyte Hodgkin lymphoma is 3–8% in adolescents and adults and 10–20% in pre‐pubertal children.

McKay P, Fielding P, Gallop-Evans E, Hall GW, Lambert J, Leach M, Marafioti T, McNamara C; British Committee for Standards in Haematology. Guidelines for the investigation and management of nodular lymphocyte predominant Hodgkin lymphoma. Br J Haematol. 2016 Jan;172(1):32-43. doi: 10.1111/bjh.13842. Epub 2015 Nov 5.PubMed PMID: 26538004.


 * 1) An initial search on PubMed using the MeSH terms of “Hodgkin’s Disease” AND “Prevalence” yielded no relevant reviews. I then conducted a literature search using PubMed with the keyword of "Nodular lymphocyte-predominant Hodgkin lymphoma". I narrowed articles to secondary articles (guidelines, practice guidelines, reviews, and systematic reviews) in the English language. Articles were sorted by “Best match”.
 * 2) Eichenauer DA, Engert A. Nodular lymphocyte-predominant Hodgkin lymphoma: a unique disease deserving unique management. Hematology Am Soc Hematol Educ Program. 2017;2017(1):324–328. doi:10.1182/asheducation-2017.1.324
 * 3) The first citation also provided prevalence information but was not transparent in its search strategy and did not seem to be a comprehensive review of the literature. The chosen resource was more transparent, showing it extensively searched relevant databases. Furthermore, the chosen article is a practice guideline from the British Journal of Haematology, which was reviewed by a guideline group of experts.
 * 4) This is a secondary source (guideline) containing references to peer-reviewed primary articles. It is published by a reputable peer-reviewed journal and is a practice guideline which is extensively reviewed by a professional medical society and represents prevailing medical consensus on the topic of Hodgkin Lymphoma. Finally, it is a recent article having been published in 2016.
 * 5) I will use this source to cite the relative prevalence of classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. This will be used in the Wikipedia article as an introduction to Hodgkin lymphoma subtypes for readers.

Assignment #3
Proposed change 1

I plan to change the "Types" subsection of "Diagnosis" within the Hodgkin's lymphoma article. I will add an introductory section which introduces the two major Hodgkin lymphoma types and their prevalence. The new sentences will state: "There are two main types of Hodgkin lymphoma: Classical  (*****all lower case: classical********)  Hodgkin lymphoma and Nodular  (*****lower case: nodular*********)  lymphocyte predominant Hodgkin lymphoma. The prevalence of classic (******* if you decide to use the terminology "classical Hodgkin lymphoma", you need to stay with it throughout your paragraph. That being said, "classic Hodgkin lymphoma" is also an accepted terminology; they are interchangeable. Since the original wiki artical used "classical", I suggest we stay with it.) Hodgkin lymphoma and nodular lymphocyte Hodgkin lymphoma are approximately 90% and 10%, respectively. "

Rationale for proposed change 1

The two introduction sentences are used to introduce the two main types of Hodgkin lymphoma, as these major types are not currently made clear for the reader. These are well-accepted classifications supported by the WHO and a practice guideline by the British Journal of Haematology and I do not forsee any controversy for the proposed change. I will also use these references to include the prevalence of each Hodgkin lymphoma type which will provide context for later sections on diagnosis and treatment. The prevalence of the two major types varies slightly depending on the source, but the WHO and practice guideline are well-accepted secondary sources that provide a reliable average prevalence.

Proposed change 2

I will create two new subheadings within "Types" titled "Classical Hodgkin lymphoma" and "Nodular lymphocyte predominant Hodgkin lymphoma". The subheading "Classical Hodgkin lymphoma" will include the current 1st, 3rd, and 4th paragraphs along with the existing table. The 2nd paragraph will then be placed under the "Nodular lymphocyte predominant Hodgkin lymphoma" subheading.

Rationale for proposed change 2

The new subheadings will help organize the "Types" paragraph into two distinct subsections. The current 1st, 3rd, and 4th paragraphs along with the table pertain to Classic Hodgkin lymphoma, while paragraph 2 only pertains to Nodular lymphocyte predominant Hodgkin lymphoma. The new organization will help the reader understand how these types are distinct and create better organization.I do not forsee any controversy for the proposed change.

Impact of bias: McKay et al.

This is a practice guideline which has been created and reviewed by experts in the field of Haematology. While the search strategy was transparent and extensive, there may be selection bias in how the articles were chosen from the literature search as the inclusion and exclusion criteria were not clearly described. In addition, the guideline only searched for articles from 1980 to the present, which may exclude some articles published prior to 1980. The expert opinions in this guideline may differ from physicians in other countries given this was published by British Haematologists.

Otherwise, this is a recent extensively reviewed resource overseen by a professional medical society and represents a prevailing medical consensus on the topic of Hodgkin lymphoma.

Impact of bias: WHO book

The book WHO: Classification of tumors hematopoietic and lymphoid tissues is an international authoritative reference guide for oncologists (*********If we are posting this paragraph on the talk page, I would suggest not to use the word "authoritative" which may be offensive to certain people. We can say "peer-reviewed" and/or "evidence-based" instead. You can also change "oncologists" to "physicians" to be more inclusive*********). There is generally a low risk of bias for this guide given it is extensively reviewed by hundreds of authors across countries. Some information may not be accurate depending on country and practice guidelines implemented. The statistic provided by the WHO book on prevalence of each Hodgkin lymphoma type uses one reference from an observational study, which may not be accurate or reliable. It is unclear whether expert opinion was also considered when publishing the statistic.