User:Nikki102010/Centroacinar cell

Lead
"Centroacinar cells are spindle-shaped cells in the exocrine pancreas". "They are small with microvilli on the apical surface". They work with organs such as the kidney, lungs, stomach, brain, intestine.

Article body
The exocrine pancreas is one of two compartments that include digestive- acting cells and duct cells. They represent an extension of the intercalated duct into each pancreatic acinus. These cells are commonly known as duct cells, and secrete an aqueous bicarbonate solution under stimulation by the hormone secretin. They also secrete mucin. '''As well as direct the pathway of the enzyme into the gut, which helps the endocrine pancreas in secreting the hormone into the circulation. This is important in glucose metabolism, insulin-producing B cells, glucagon-producing A cells and somatostatin producing δ cells.'''

The intercalated ducts take the bicarbonate to intralobular ducts which become lobular ducts. These lobular ducts finally converge to form the main pancreatic duct. '''These pancreatic ducts can act as a response mechanism when injury occurs and to avoid disruptions in the pancreatic lumen. This keeps the ionic content in check while keeping it open for flow to occur. Mutations that can occur because of blockage/ accumulation in the pancreatic duct are disorders such as cystic fibrosis.'''