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= M22 (New York City bus) = The M22 bus route constitutes a public transit line in Manhattan, New York City. The M22 operates between Battery Park City and the Lower East Side serving as a crosstown route along Madison Street and Chambers Street.

Current route
In the eastbound direction, the M22 bus starts at Vesey Street and North End Avenue in Battery Park City, travelling north along North End Avenue until it turns right onto Chambers Street. The M22 then turns right onto Broadway, and heads east along Park Row and south along Frankfort St. Buses continue northeast along Pearl St and St. James Place before turning east onto Madison Street. The M22 continues east along Madison Street until Madison Street merges with Grand Street and terminates at Grand Street and FDR Drive in the Lower East Side.

In the westbound direction, the M22 starts at Grand Street and FDR Drive in the Lower East Side, heading south along the FDR Drive, west along Cherry Street, north along Jackson Street, and west along Madison Street. The bus continues west along Madison Street until Pike Street, where it turns north and then turns west onto East Broadway. At Bowery, East Broadway becomes Worth Street, and the M22 turns south along Federal Plaza and Centre Street, then west onto Chambers St. The M22 then turns south onto North End Ave, east onto Murray Street, and south along West Street before turning west onto Vesey Street and terminating at Vesey Street and North End Ave in Battery Park City.

History
On September 21, 1919, the New York Railway's Madison and Chambers Streets Line streetcar was replaced by the New York City Department of Plant and Structures M1 bus route. This bus route was renumbered as the M22 on July 1, 1974. On June 27, 2010, overnight bus service on the M22 was discontinued due to a budget crisis.