User:Nrsharkey/sandbox

Article Evaluation:

Each fact in the wikipedia article is cited correctly with appropriate sources. One of the largest contributions to the article is women in physiology and in this area it might be better to have it dedicated to notable people in physiology instead. Other than this most of the sources come from peer reviewed articles, but there are some sources that come from websites and other weak sources.

Histotoxic hypoxia draft:

Histotoxic hypoxia can be a consequence of ischemia in the case of stroke or inflammation. In the case of inflammation, neuro-inflammatory deseases like Alzheimer's disease, Parkinson's disease and Multiple Sclerosis can all lead to histotoxic hypoxia. During a stroke, there is an interruption in the blood supply followed by reperfusion which leads to histotoxic hypoxia because of an accumulation of reactive oxygen species (ROS). In the case of inflammatory diseases, histotoxic hypoxia can also be triggered by ROS from mitochondrial damage in the active lesions of chronic multiple sclerosis. Inflammatory mediators such as heme oxygynase-1(HO-1) can result in histotoxic hypoxia when they are released in excess and cause the sequestration of iron as in the cases of Alzheimer's disease, Parkinson's disease and Multiple Sclerosis.