User:Nstynka/Lineweaver–Burk plot/Mrothroc Peer Review

General info

 * Whose work are you reviewing?

Nstynka


 * Link to draft you're reviewing
 * User:Nstynka/Lineweaver–Burk plot
 * Link to the current version of the article (if it exists)
 * Lineweaver–Burk plot

Lead
I like that you added the use of the Lineweaver-Burk plot and what variables you can find by using the graph. However, I do think your statement could use a little clarification. Maybe say that you can compare a Lineweaver-Burk plot with no inhibitor to one with an inhibitor and find out how the inhibitor is competing with the enzyme. What you wrote makes sense to me but maybe someone with not as much background wouldn't understand exactly what you mean. I like that you included alternatives to the Lineweaver-Burk plot for calculating the same variables mentioned above. Concise good introduction overall.

I like that you included definitions of the variables that can be found- did a good job of defining them concisely and stating their relevance or how to find them on the chart. Only variable I'm unsure of is the alpha- don't know what that represents from the way definition was written.

Derivation section nice and concise and with pics from original article, makes sense.

Applications
I like how you separated the different types of enzyme inhibition and with pictures of the graphs I think this gives an overall quick and concise picture of the applications of the plot. Only thing I'm unsure of from what you've written is maybe include what the slope changing or remaining the same indicates. Also, I personally am still a little confused on the alpha variable like I mentioned above.

Problems with Lineweaver-Burk
I like that you included the errors that can enhance when taking the reciprocal of the variables, and the reasoning as to why increased error is observed (like decreased solubility).

Overall Evaluation
Overall I think you improved this article a lot. I think you added important new information and more cohesively structured the existing information. I think clarifying the few things I mentioned that I misinterpreted or misunderstood personally, might make the article more accessible for a more general audience.

~mrothroc