User:OGMich/Retinoic acid receptor

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'''RARs also play a crucial role in embryonic development. Mice knockout studies of RARs revealed that knocking out RARs could fully replicate the spectrum of defects associated with fetal vitamin A deficiency syndrome, unveiling additional abnormalities beyond previously known vitamin A functions. Notably, double RAR mutants exhibited the most severe defects, including ocular and cardiovascular defects, indicating some level of redundancy among RARs. RXR/RAR heterodimers transmit retinoid signals in diverse ways to control the expression of networks of RA target genes. This process plays a crucial role in shaping both the axial and limb patterning during early embryo development, as well as influencing various aspects of organ formation in later stages of development.'''