User:OSandoval Future UCSF PharmD/sandbox

Uterotonics
Proposed changes to Prostaglandins subsection:


 * 1) Overview of the mechanism of action of prostaglandins and its role in labor induction.
 * 2) Including more information on each of the prostaglandin types, providing necessary links to their respective articles.
 * 3) Reorganizing the subsection for coherency and avoiding duplicate information.

Prostaglandins
Prostaglandins are derived from the cell membrane phospholipids through a series of enzymatic reactions. Phospholipase A2 cleaves arachidonic acid from membrane phospholipids and is eventually converted to prostaglandins by cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Due to this mechanism, prostaglandins have a presence in many areas of the body and allow for diverse physiological and pathological functions. Primarily known for its role in mediating inflammation, pain, swelling, redness, and warmth, prostaglandin synthesis is a target for many drugs. Inhibition of COX-1 and COX-2 by aspirin and non-steroidal anti-inflammatory drugs prevents the inflammatory response and can also prevent homeostatic functions of the stomach and GI system.

Dinoprost: also known as PGF 2α, is a naturally occurring prostaglandin which causes contraction via PG F receptors. Dinoprost was discontinued in 2015.

Carboprost: an analogue of PGF 2α, this prostaglandin contains oxytocic properties that permit a longer duration of action than the naturally occurring prostaglandins. The injectable prostaglandin is administered via intramuscularly or intramyometrial, and is contraindicated in those with reactive airway diseases. Side effects of this medication include hypertension, hypotension, pulmonary hypertension, vomiting and diarrhea.

Misoprostol: an analogue of PGE1, this injectable PG is a popular choice for PPH prophylaxis and treatment. Misoprostol is easily administered, considered safe, and its low cost. The routes of administration include sublingual, oral, vaginal, and rectal with greatest efficacy from sublingual and vaginal administration. Misoprostol is an agonist of EP1 and EP3 receptors, and can cause a greater stimulation at lower concentrations. At higher concentrations, the medication can suppress contractions.

Peer Review
Do the group’s edits substantially improve the article as described in the Wikipedia peer review “Guiding framework”?

Yes, the group did an excellent job updating the article with pertinent information. They have provided information on pathophysiology, treatment, classifications, complications, and epidemiology. Overall this wikipedia article has vastly been improved by Group 31.

Has the group achieved its overall goals for improvement?

The goals for improvement were not stated, however, looking at the previous version of the article before Group 31 started editing, they have made a great improvement on the article.

Are the edits formatted consistent with Wikipedia’s manual of style?

Overall the edits are formatted consistently with Wikipedia's manual of style, however, there are a few instances where lay language can be used so the article is not written for healthcare professionals in mind.

Paragraph: Set the style of your text. For example, make a header or plain paragraph text. You can also use it to offset block quotes.
A : Highlight your text, then click here to format it with bold, italics, etc. The “More” options allows you to underline (U), cross-out text (S) , , change language keyboards (Aあ), and clear all formatting.

Links: Highlight text and push this button to make it a link. The Visual Editor will automatically suggest related Wikipedia articles for that word or phrase. This is a great way to connect your article to more Wikipedia content. You only have to link important words once, usually during the first time they appear. If you want to link to pages outside of Wikipedia (for an “external links” section, for example) click on the “External link” tab.

Cite: The citation tool in the Visual Editor helps format your citations. You can simply paste a DOI or URL, and the Visual Editor will try to sort out all of the fields you need. Be sure to review it, however, and apply missing fields manually (if you know them). You can also add books, journals, news, and websites manually. That opens up a quick guide for inputting your citations. Once you've added a source, you can click the “re-use” tab to cite it again.

Insert: This tab lets you add media, images, or tables.
 * Bullets: To add bullet points or a numbered list, click here.

Ω: This tab allows you to add special characters, such as those found in non-English words, scientific notation, and a handful of language extensions.°

Cite this.