User:Oalnafo1/sandbox

this is oalnafo1's sandbox. testing 1,2. =Five pillars summary= Online encyclopedia As objective as possible ##incomplete

=Summary of characteristics of target article= Our article should be between B and GA article quality ratings.

B
A B-rated article is suitably referenced, shows reasonable coverage, structured, reasonably well-written, contains illustrations, presented for a relatively general audience. More information on this rating can be found here.

GA
GA stands for "good article" and is characterized by the following: well-written, verifiable with no original research, broad in its coverage, neutral, stable, and illustrated. A more detailed description can be found here.

Differences between B and GA
The main difference between the two ratings is stage of development with B-rated articles being just below the complete and GA-rated articles attaining completeness through peer-review and polishing.

=Aging and Mitochondria= There are many links between physiological aging and mitochondrial. One link is found in people with Hutchinson-Gilford progeria who experience symptoms that resemble the normal aging phenotype; the gene responsible for the syndrome, progerin, has been shown to cause mitochondrial dysfunction in human skin fibroblasts and mouse models. Additionally, it has been shown that dietary restriction, a widely-supported method of lifespan extension, attenuates the loss of mitochondrial biogenesis associated with aging. Hutchinson-Gilford progeria express decreased abundances of mitochondria which also suggests reduced mitochondrial biogenesis in that syndrome. More investigation into this association is required because the role of mitochondrial biogenesis may not be causative.