User:Onefreetrajectory/sandbox

Rayaldee is a vitamin D prohormone drug for the treatment of Secondary Hyperparathyroidism (SHPT) in stage 3 and 4 Chronic Kidney Disease (CKD) patients with vitamin D deficiency. Rayaldee is a proprietary modified-release formulation of Calfifediol designed to gradually and reliably raise serum total 25-hydroxyvitamin D (prohormone) concentrations to targeted levels while avoiding upregulation of, a cytochrome P-450 enzyme that reduces the Parathyroid Hormone lowering potency of current vitamin D supplements. Activation of the vitamin D prohormone by the kidney is tightly regulated, preventing excessive elevation of serum calcium and related side effects which encumber other vitamin D hormone therapies and promote vascular and renal calcification.