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Reactions of Anaplerotic metabolism

Anaplerotic Reactions, coined by Hans Kornberg originate from the Greek ....

Pancreatic β-cells that regulate blood glucose level by secreting insulin in response to high blood glucose level, contain high amounts of pyruvate carboxylase.

A decrease in insulin secretion and anaplerotic activity has been found in β-cells that do not have hypoxia-inducible factor-1 beta.

Anaplerotic enzyme mediate an alternative pathway to insulin secretion through aiding the production of cytosolic signal molecules.

Reginald Garrett, Charles Grisham, biochemistry, Cengage Learning,USA, 2017, page number 664, 6th edition, 978-1-305-57720-6