User:Overcoming hurdles/RAC3

Location
Rac3 gene is located in the third sub-band of the fifth band in the second region of the q arm on chromosome 17. There’s many tumor suppressor genes that are located around the Rac3 gene.

Therapeutic Use
Since the Rac3 gene is over-expressed in carcinoma cells, it can function as a therapeutic target for the treatment of different cancer such as lung adenocarcinoma. To become invasive, epithelial cells have to transform into mesenchymal cells and the transformation is regulated by the Rac3 gene. As a result, if the Rac3 gene is silenced, then lung adenocarcinoma cells cannot metastasize. In addition, drugs designed to silence the Rac3 gene can lead to the apoptosis of tumor cells, thus preventing the cells from colonizing.